Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Drug Delivery Approaches with Special Emphasis on Chemical Drug Delivery

Apv Focus Group Drug Delivery

For the second time in the last three years the Skin Forum held its Annual Meeting in conjunction with the APV. This time the meeting took place in Prague at the IMG Conference Centre with the APV Headquarters in the form of Dr. Bornhöft and Ms. Schmidt leading the meeting organizational efforts. About 200 skin scientists attended the meeting and gave it, with their discussions in the lectures ...

Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low. In order to expand current research it is important to know which receptors are selec...

Membrane transporter proteins: a challenge for CNS drug development

Drug transporters are membrane proteins present in various tissues such as the lymphocytes, intestine, liver, kidney, testis, placenta, and central nervous system. These transporters play a significant role in drug absorption and distribution to organic systems, particularly if the organs are protected by blood-organ barriers, such as the blood-brain barrier or the maternal-fetal barrier. In co...

Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs

Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to concomitantly administered drugs that interfere with drug transport may alter the kinetics of drug substrates. In vitro and in vivo studies indicate ...